Detailed view for Smp_162090
Basic information
Schistosoma mansoni, subfamily S1B unassigned peptidase (S01 family)
Source Database / ID: GeneDB
pI: 7.5732 |
Length (AA): 1171 |
MW (Da): 125235 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Network
Pfam domains
Gene Ontology
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0048037 cofactor binding
GO:0015078 hydrogen ion transmembrane transporter activity
GO:0005515 protein binding
GO:0005488 binding
GO:0004252 serine-type endopeptidase activity
GO:0003824 catalytic activity
GO:0051287 NAD binding
GO:0015991 ATP hydrolysis coupled proton transport
GO:0015986 ATP synthesis coupled proton transport
GO:0008152 metabolic process
GO:0006508 proteolysis
GO:0055114 oxidation reduction
Metabolic Pathways
Structural information
Modbase 3D models:
There are 8 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
| Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
|---|---|---|---|---|---|---|---|---|---|
| 13 | 417 | 1ygy (A) | 3 | 400 | 30.00 | 0 | 1 | 0.663558 | 0.13 |
| 14 | 343 | 2ome (A) | 33 | 362 | 72.00 | 0 | 1 | 1.19851 | -1.06 |
| 433 | 605 | 2kr0 (A) | 129 | 274 | 35.00 | 0.087 | 0.13 | -0.011763 | 3.06 |
| 517 | 869 | 1u7l (A) | 13 | 349 | 32.00 | 0 | 1 | 0.703152 | -0.41 |
| 541 | 905 | 1u7l (A) | 32 | 392 | 33.00 | 0 | 1 | 0.626799 | -0.17 |
| 875 | 1171 | 5y28 (A) | 21 | 350 | 31.00 | 0 | 1 | 0.323329 | 0.81 |
| 895 | 1102 | 5y2d (A) | 42 | 307 | 33.00 | 0 | 1 | 0.575126 | -0.64 |
| 909 | 1081 | 3nwu (B) | 185 | 364 | 49.00 | 0 | 1 | 0.703437 | -0.55 |
Help me make sense of these data.
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Expression
Orthologs
Ortholog group members (OG5_129666)
| Species | Accession | Gene Product |
|---|---|---|
| Arabidopsis thaliana | AT1G01510 | C-terminal binding protein AN |
| Brugia malayi | Bm1_40340 | C-terminal binding protein |
| Caenorhabditis elegans | CELE_F49E10.5 | Protein CTBP-1, isoform A |
| Drosophila melanogaster | Dmel_CG7583 | C-terminal Binding Protein |
| Echinococcus granulosus | EgrG_000816400 | Zinc finger C2CH type |
| Echinococcus granulosus | EgrG_000977300 | serine protease HTRA2 mitochondrial |
| Echinococcus granulosus | EgrG_000977100 | V type proton ATPase subunit C 1 A |
| Echinococcus granulosus | EgrG_001081400 | subfamily S1B unassigned peptidase S01 family |
| Echinococcus multilocularis | EmuJ_000977300 | serine protease HTRA2, mitochondrial |
| Echinococcus multilocularis | EmuJ_000977100 | V type proton ATPase subunit C 1 A |
| Echinococcus multilocularis | EmuJ_001081400 | subfamily S1B unassigned peptidase (S01 family) |
| Echinococcus multilocularis | EmuJ_000816400 | Zinc finger, C2CH type |
| Homo sapiens | 1488 | C-terminal binding protein 2 |
| Homo sapiens | ENSG00000159692 | C-terminal binding protein 1 |
| Loa Loa (eye worm) | LOAG_02007 | hypothetical protein |
| Mus musculus | ENSMUSG00000037373 | C-terminal binding protein 1 |
| Mus musculus | ENSMUSG00000030970 | C-terminal binding protein 2 |
| Oryza sativa | 4349220 | Os10g0533000 |
| Oryza sativa | 4331469 | Os03g0126100 |
| Schistosoma japonicum | Sjp_0077250 | ko:K04496 C-terminal binding protein, putative |
| Schistosoma japonicum | Sjp_0214220 | ko:K01535 H+-transporting ATPase [EC3.6.3.6], putative |
| Schistosoma mansoni | Smp_162090 | subfamily S1B unassigned peptidase (S01 family) |
| Schmidtea mediterranea | mk4.001080.00 | C-terminal-binding protein 1 |
| Schmidtea mediterranea | mk4.007505.00 | |
| Trichomonas vaginalis | TVAG_299140 | 2-hydroxyacid dehydrogenase, putative |
Essentiality
Phenotypes and Validation (curated)
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Annotated validation
Associated compounds / Druggability
Known modulators for this target
Predicted associations
By orthology with druggable targets
| Species | Known druggable target | Linked compounds | Reference |
|---|---|---|---|
| Homo sapiens | C-terminal binding protein 2 | Compounds | References |
By sequence similarity to non orthologous druggable targets
| Species | Target | Length | Identity | Alignment span | Linked Drugs | Reference |
|---|---|---|---|---|---|---|
| Manduca sexta | V-type proton ATPase subunit C | 385 aa | 57.3% | 316 aa | Compounds | References |
Obtained from network model
Assayability
Assay information
Reagent availability
Bibliographic References